Ccl5 (NM_013653) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Mouse CCL5, the region of Ser24 - Ala91, from gene Accession# NM_013653
Tag	Tag Free
Predicted MW	7.8 kDa
Concentration	lot specific
Purity	>90%, as determined by Coomassie stained SDS-PAGE.
Buffer	0.1 M Glycine, 0.15 M NaCl buffer, pH 3.0
Storage	Store at -80°C.
Stability	Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Bioactivity	Bioactivity was measured by its ability to chemoattract Baf3-hCCR5 cells in a dose dependent manner.
Endotoxin	Less than 0.01 ng per µg protein as determined by the LAL method
Reference Data
RefSeq	NP_038681
Locus ID	20304
UniProt ID	P30882
Refseq Size	579
Cytogenetics	11 50.66 cM
Refseq ORF	273
Synonyms	MuRantes; RANTES; Scya5; SISd; TCP228
Summary	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.[UniProtKB/Swiss-Prot Function]

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