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SIRP alpha (SIRPA) Human Recombinant Protein
CAT＃: TP723932
Human SIRP alpha Protein, hFc-His Tag
View other "SIRP alpha" proteins (13)
|
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CNY 5,876.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence |
SIRPα（Glu31-Arg370）+hFc（Glu99-Ala330）+6×His tag
|
| Tag | C-Human Fc and 6×His |
| Predicted MW | 70-98 kDa |
| Purity | > 95% |
| Buffer | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization |
| Preparation | Affinity purification |
| Applications | ELISA |
| Storage | Store the lyophilized protein at -20°C. After reconstitution, store the protein at -80°C for 12 months. Avoid repeated freezing and thawing. |
| Stability | 12 months from date of despatch |
| Reference Data | |
| Locus ID | 140885 |
| UniProt ID | P78324 |
| Summary | Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. |
| Protein Families | ELISA |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC409074 | SIRPA HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421878 | SIRPA HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC421879 | SIRPA HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LY409074 | Transient overexpression lysate of signal-regulatory protein alpha (SIRPA), transcript variant 3 |
CNY 3,080.00 |
|
| LY421878 | Transient overexpression lysate of signal-regulatory protein alpha (SIRPA), transcript variant 1 |
CNY 4,840.00 |
|
| LY421879 | Transient overexpression lysate of signal-regulatory protein alpha (SIRPA), transcript variant 2 |
CNY 4,840.00 |
|
| PH307315 | SIRPA MS Standard C13 and N15-labeled recombinant protein (NP_542970) |
CNY 19,520.00 |
|
| PH316320 | SIRPA MS Standard C13 and N15-labeled recombinant protein (NP_001035112) |
CNY 19,520.00 |
|
| PH322380 | SIRPA MS Standard C13 and N15-labeled recombinant protein (NP_001035111) |
CNY 19,520.00 |
|
| TP307315 | Recombinant protein of human signal-regulatory protein alpha (SIRPA), transcript variant 3, 20 µg |
CNY 2,900.00 |
|
| TP316320 | Recombinant protein of human signal-regulatory protein alpha (SIRPA), transcript variant 2, 20 µg |
CNY 2,900.00 |
|
| TP322380 | Recombinant protein of human signal-regulatory protein alpha (SIRPA), transcript variant 1, 20 µg |
CNY 2,900.00 |
|
| TP762372 | Purified recombinant protein of Human signal-regulatory protein alpha (SIRPA), transcript variant 1, Glu31-Ile373, with N-terminal His tag, expressed in E.coli, 50ug |
CNY 1,950.00 |
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