Human ITGA2 & ITGB1 Heterodimer Protein, His Tag & hFc Tag
CAT#: TP724272
Human ITGA2 & ITGB1 Heterodimer Protein, His Tag & hFc Tag
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CNY 5,780.00
货期*
2周
规格
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Specifications
Product Data | |
Expression Host | HEK293 |
Tag | C-6×His tag and C-Human Fc |
Predicted MW | The heterodimer protein has a predicted molecular mass of 121.8 kDa and 104.5 kDa separately after removal of the signal peptide. |
Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
Storage | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Stability | 12 months from date of despatch |
Reference Data | |
Summary | Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection. |
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