S Protein SARS-CoV-2 Recombinant Protein
CAT#: TP724614
Recombinant SARS-CoV-2 Spike Protein (RBD) (C-His, HEK293)
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CNY 3,140.00
货期*
2周
规格
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Specifications
Product Data | |
Species | SARS-CoV-2 |
Protein Source | HEK293 |
Expression cDNA Clone or AA Sequence |
319-532
|
Tag | C-8His |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH7.4 |
Note | Recombinant SARS-CoV-2 Spike Protein is produced by HEK293. The target gene encoding 319-532 is expressed with a 8His tag at the C terminus. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 43740568 |
Synonyms | Spike Receptor Binding Domain; Spike RBD |
Summary | The SARS-CoV-2 Spike Protein is a glycoprotein expressed in various cell types, which may support its involvement in the innate immune response. Receptors that bind S1 include ACE2, DPP4, and CEACAM. The spike (S) glycoprotein is essential for binding the virus to the host cell during the infection process, as seen in severe acute respiratory syndrome (SARS). In SARS-CoV, the S glycoprotein alone facilitates membrane fusion for virus entry and cell fusion, making it a significant immunogen and entry inhibitor target. Reports show that the 2019-nCoV can infect human respiratory epithelial cells by interacting with the human ACE2 receptor. The spike protein is a type I transmembrane protein containing two subunits: S1 and S2. S1 includes the receptor-binding domain (RBD), which recognizes the cell surface receptor, and S2 includes basic elements needed for membrane fusion. The S protein is crucial in inducing neutralizing-antibody, T-cell responses,and providing protective immunity. |
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