ALDH1A2 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Met1-Ser518
Tag	N-6His
Buffer	Lyophilized from a 0.2 um filtered solution of 20mM HEPES,150mM KCl,1mM β-ME ,0.5mM EDTA ,pH7.5.
Note	Recombinant Human Aldehyde Dehydrogenase 1-A2 is produced by E.coli. The target gene encoding Met1-Ser518 is expressed with a 6His tag at the N terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	8854
UniProt ID	O94788
Synonyms	Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2;RALDH(II); Retinal dehydrogenase 2; ALDH1A2; RALDH2
Summary	Aldehyde dehydrogenase 1 family member A2 (ALDH1A2), also known as retinaldehyde dehydrogenase 2 (RALDH2), belongs to the aldehyde dehydrogenase family which contains two members, the ALDH1 s (ALDH1A1, ALDH1A2 and ALDH1A3) and the 9-cis retinaldehyde dehydrogenase ALDH8 s. ALDH1A2 is a key enzyme that converts retinoic acid (RA) to retinaldehyde. RA is a paracrine hormone signaling molecule that functions in developing and adult tissues. ALDH1A2 was also found to regulate normal and tumor cell growth and differentiation in several cancers. Studies showed that ALDH1A2 expression is increased after the appearance of AraC resistance in clinical cases, which means this protein is effective in AraC resistance.
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Retinol metabolism

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