IL2 Receptor beta (IL2RB) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A27-T240
Tag	N-Avi&6His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant human interleukin-2 receptor subunit beta is produced by Human 293 Cells. The target gene encoding A27-T240 is expressed with a Avi&;6His tag at the N terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	3560
UniProt ID	P14784
Synonyms	Interleukin-2 receptor subunit beta;IL2RB;IL-2 receptor subunit beta;IL-2R subunit beta;High affinity IL-2 receptor subunit beta;CD122
Summary	Interleukin-2 receptor subunit beta (IL2RB) belongs to the type I cytokine receptor family and it is expressed in mononuclear cells. IL2RB contains a fibronectin type-III domain. IL2RB / CD122 is involved in T cell-mediated immune responses and is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. IL2RB is the receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2RB might also be in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Endocytosis, Jak-STAT signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.