Il11 Mouse Recombinant Protein
CAT#: TP724635
Recombinant Mouse Interleukin-11/IL-11 (N-His)
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CNY 3,140.00
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Specifications
Product Data | |
Species | Mouse |
Protein Source | E. coli |
Expression cDNA Clone or AA Sequence |
G23-L199
|
Tag | N-6His |
Buffer | Supplied as a 0.2 um filtered solution of 2umM Tris-HCl, 30umM NaCl, 10% Glycerol, pH8.0. |
Note | Recombinant Mouse Interleukin-11 is produced by E.coli. The target gene encoding G23-L199 is expressed with a 6His tag at the N terminus. |
Storage | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 16156 |
UniProt ID | P47873 |
Synonyms | Interleukin-11; IL-11; Adipogenesis Inhibitory Factor; AGIF; Oprelvekin; IL11 |
Summary | Interleukin 11 (IL-11) is a pleiotropic cytokine that belongs to the IL-6 family. As a thrombopoietic growth factor, IL-11 directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. IL-11 also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2, it activates a signaling cascade that promotes cell proliferation. The signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. IL-11 is found to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation, and could be used as a therapeutic for osteoporosis. |
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