Osteoprotegerin (TNFRSF11B) Human Recombinant Protein

CAT#: TP724644

Recombinant Human Osteoprotegerin/OPG/TNFRSF11B (C-His)



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CNY 3,140.00


货期*
5周

规格
    • 10 ug

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Specifications

Product Data
Species Human
Protein Source Human 293
Expression cDNA Clone or AA Sequence
Tag C-8His
Buffer Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note Recombinant Human Osteoprotegerin is produced by Human 293 Cells. The target gene encoding E22-L401 is expressed with a 8His tag at the C terminus.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Locus ID 4982
UniProt ID O00300
Synonyms Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis InhibitoryFactor; Osteoprotegerin; TNFRSF11B; OCIF; OPG
Summary Osteoprotegerin (OPG) is a secreted homodimer protein that belongs to tumor necrosis factor receptor superfamily. OPG is highly expressed in fetal kidney, liver and lung. It is up-regulated by increasing calcium-concentration in the medium and estrogens and down-regulated by glucocorticoids. OPG can have multiple effects on TNFSF10 and TNFSF11. As a decoy receptor for TNFSF11/RANKL, OPG neutralizes its function in osteoclastogenesis. OPG also inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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