Osteoprotegerin (TNFRSF11B) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) E22-L401
Tag	C-8His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Human Osteoprotegerin is produced by Human 293 Cells. The target gene encoding E22-L401 is expressed with a 8His tag at the C terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	4982
UniProt ID	O00300
Synonyms	Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis InhibitoryFactor; Osteoprotegerin; TNFRSF11B; OCIF; OPG
Summary	Osteoprotegerin (OPG) is a secreted homodimer protein that belongs to tumor necrosis factor receptor superfamily. OPG is highly expressed in fetal kidney, liver and lung. It is up-regulated by increasing calcium-concentration in the medium and estrogens and down-regulated by glucocorticoids. OPG can have multiple effects on TNFSF10 and TNFSF11. As a decoy receptor for TNFSF11/RANKL, OPG neutralizes its function in osteoclastogenesis. OPG also inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction

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