CNTF Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A2-P187
Buffer	Lyophilized from a 0.2 um filtered solution of 2umM Tris, 30umM NaCl, 0.5%CHAPS, 0.umM TCEP, 0.umM EDTA, pH8.0
Note	Recombinant Human Ciliary Neurotrophic Factor is produced by E.coli. The target gene encoding A2-P187 is expressed.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	1270
UniProt ID	P26441
Synonyms	Ciliary Neurotrophic Factor; CNTF
Summary	Ciliary neurotrophic factor (CNTF) is a polypeptide hormone that belongs to the cytokine family. CNTF facilitates neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. CNTF has biological effects through the activation of a multi-subunit receptor complex, consisting of an extracellular CNTF binding subunit (CNTF?) and two transmembrane signal transduction proteins: glycoprotein gp13 and LIF receptor. CNTF is shown as a potent survival factor of neurons and oligodendrocytes, associated with reducing tissue destruction during inflammatory attacks. Studies showed that CNTF could be an agent that has therapeutic potential and possibly induces differentiation of large multipolar ganglionic phenotype in a subset of progenitors.
Protein Families	Druggable Genome
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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