Her2 (ERBB2) Human Recombinant Protein

CAT#: TP724766

Recombinant Human ERBB2 (C-His)



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CNY 3,140.00


货期*
5周

规格
    • 50 ug

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经常一起买 (1)
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Specifications

Product Data
Species Human
Protein Source E. coli
Expression cDNA Clone or AA Sequence
Tag C-His
Buffer Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Note Recombinant Human ERBB2 (C-His) is produced by E.coli. The target gene encoding Cys511-Pro644 is expressed with a C-His tag.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Locus ID 2064
UniProt ID P04626
Synonyms ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1
Summary Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Calcium signaling pathway, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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