Cynomolgus Recombinant Protein

CAT#: TP724777

Recombinan Cynomolgus MerTK (C-His)



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CNY 3,140.00


货期*
5周

规格
    • 50 ug

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Specifications

Product Data
Species Cynomolgus
Protein Source Human
Expression cDNA Clone or AA Sequence
Tag C-His
Buffer Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Note Recombinan Cynomolgus MerTK (C-His) is produced by Human Cells. The target gene encoding Met1-Pro734 is expressed with a C-His tag.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Synonyms MERTK,Mer
Summary Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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