IL3RA Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Lys20-Arg305
Tag	C-hFc
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Human Interleukin-3 Receptor Subunit Alpha is produced by our Mammalian expression systemand the target gene encoding Lys20-Arg305 is expressed with a Fc tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	3563
UniProt ID	P26951
Synonyms	Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha;IL-3RA; IL3RA;CD123
Summary	CD123, also known as Interleukin-3 receptor subunit alpha, is a glycoprotein that belongs to the type I cytokine receptor family. CD123 is a heterodimer with an alpha and a beta subunit. The alpha subunit alone binds IL‑3 with low affinity. The beta subunit does not bind IL‑3 by itself but is required for the high‑affinity binding of IL‑3 to the heterodimeric receptor complex. CD123 induces the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as a variety of lineage‑committed cells. CD123 has been identified as a potential immunotherapeutic target due to its overexpression in AML compared with normal hematopoietic stem cells.
Protein Families	Transmembrane
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

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