IGFBP7 Human Recombinant Protein
CNY 3,140.00
货期*
2周
规格
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经常一起买 (1)
Specifications
Product Data | |
Species | Human |
Protein Source | Human 293 |
Expression cDNA Clone or AA Sequence |
Ser27-Leu282
|
Tag | C-6His |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, 0.05%Tween 80, pH7.4 |
Note | Recombinant Human Insulin-like Growth Factor-binding Protein 7 is produced by our Mammalian expression system and the target gene encoding Ser27-Leu282 is expressed with a 6His tag at the C-terminus. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 3490 |
UniProt ID | Q16270 |
Synonyms | Insulin-like growth factor-binding protein 7;IGFBP7;IGF-binding protein 7;IGFBP-rP1;MAC25 protein;Tumor-derived adhesion factor;TAF |
Summary | Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that is a member of the insulin-like growth factor (IGF) binding proteins superfamily. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. IGFBP7 is expressed in multiple normal tissues as well as cancer cells. It is highly expressed in high endothelial venules (HEVs) of blood vessels in the secondary lymphoid tissues. IGFBP7 interacts with heparan sulfate proteoglycans, type IV collagen, and specific chemokines. It supports weak cell adhesion, facilitates cell spreading on type IV collagen, and stimulates the production of the potent vasodilator PGI2. In addition, IGFBP7 modulates tumor cell growth and has also been implicated in angiogenesis. |
Protein Families | Secreted Protein |
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