SIRP alpha (SIRPA) Human Recombinant Protein

CAT#: TP725143

Recombinant Human SIRP alpha/CD172a (C-His)



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CNY 3,140.00


货期*
5周

规格
    • 10 ug

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经常一起买 (1)
SIRPA mouse monoclonal antibody, clone OTI7B3 (formerly 7B3)
    • 100 ul

CNY 1,999.00
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Specifications

Product Data
Species Human
Protein Source Human 293
Expression cDNA Clone or AA Sequence
Tag C-6His
Buffer Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4
Note Recombinant Human SIRP alpha is produced by our Mammalian expression system and the target gene encoding Glu31-Arg370 is expressed with a 6His tag at the C-terminus.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Locus ID 140885
UniProt ID P78324
Synonyms SHP Substrate 1; SHPS-1; CD172 Antigen-Like Family Member A; Inhibitory Feceptor SHPS-1; Macrophage Fusion Receptor; MyD-1 Antigen; Signal-Regulatory Protein Alpha-1; Sirp-Alpha-1; Sirp-Alpha-2; Signal-Regulatory Protein Alpha-3; Sirp-Alpha-3; p84; CD172a; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP
Summary Signal regulatory protein alpha (SIRPα) is a monomeric type I transmembrane glycoprotein, that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily. SIRPα can express in a variety of tissues, mainly in brain and myeloid cells, such as macrophages, neutrophils, dendritic and Langerhans cells. It is also found in neurons, smooth muscle and endothelial cells. SIRPα is an immunoglobulin-like cell surface receptor for CD47. Its binding to CD47 prevents the maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. SIRPα also acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα holds the adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a critical role in intracellular signaling during synaptogenesis and in synaptic function.
Protein Families Druggable Genome, Phosphatase, Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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