IL1 Receptor I (IL1R1) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Asp21-Pro330
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Human IL-1R-1 is produced by our Mammalian expression system and the target gene encoding Asp21-Pro330 is expressed with a 6His tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	3554
UniProt ID	P14778
Synonyms	Interleukin-1 receptor type 1; IL-1R-1; IL1R1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; p80; CD121a
Summary	Interleukin 1 receptor, type I (IL-1R1) is an interleukin receptor that is a member of the interleukin-1 receptor family. IL-1R1 is expressed predominantly by T cells, fibroblasts, and endothelial cells. IL-1R1 mediates numerous cytokine-induced immune and inflammatory responses. It binds to interleukin-1 along with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binding of IL-1R1 to antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway

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