FLT3 Human Recombinant Protein
CNY 3,140.00
货期*
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经常一起买 (1)
FLT3 mouse monoclonal antibody, clone OTI7D6 (formerly 7D6)
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Species | Human |
Protein Source | Human 293 |
Expression cDNA Clone or AA Sequence |
Val320-Asp469
|
Tag | C-FLAG-6His |
Buffer | Supplied as a 0.2 um filtered solution of PBS, pH7.4 |
Note | Recombinant Human FLT (V320-D469) is produced by our Mammalian expression system and the target gene encoding Val320-Asp469 is expressed with a FLAG and a 6His tag at the C-terminus. |
Storage | Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 2322 |
UniProt ID | P36888 |
Synonyms | Receptor-type tyrosine-protein kinase FLT3, CD135, STK-1, FLK-2 |
Summary | Tyrosine-protein kinase acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and dendritic cells. It stimulates phosphorylation of SHC1 and AKT1, and activates the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. It can be used as a diagnostic tool to establish the exact cause of acute myeloid leukemia and to determine the optimal therapy. |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
Protein Pathways | Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer |
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