CD252 (TNFSF4) Human Recombinant Protein
CAT#: TP725228
Recombinant Human OX40L/TNFSF4 (N-His)
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CNY 3,140.00
货期*
2周
规格
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经常一起买 (1)
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Specifications
Product Data | |
Species | Human |
Protein Source | Human 293 |
Expression cDNA Clone or AA Sequence |
Gln51-Leu183
|
Tag | N-8His |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH7.4 |
Note | Recombinant Human OX40 Ligand is produced by our Mammalian expression system and the target gene encoding Gln51-Leu183 is expressed with a 8His tag at the N-terminus. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 7292 |
UniProt ID | P23510 |
Synonyms | Tumor necrosis factor ligand superfamily member 4;Glycoprotein Gp34;OX40 ligand;CD252;TAX transcriptionally-activated glycoprotein 1;TXGP1 |
Summary | OX40L, also known as CD252 is a type II transmembrane glycoprotein that is a member of the tumor necrosis factor (TNF) ligand family. OX40L is expressed on the surface of activated B cells, T cells, dendritic cells, and endothelial cells. It is an essential co-stimulatory molecule that plays an important role in the regulation of T-cell-mediated immunity. OX40L might play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. The interaction of OX40 and OX40L on activated T cells in situ in tumors has been found to facilitate immune responses and subsequent tumor regression. |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Cytokine-cytokine receptor interaction |
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