CD252 (TNFSF4) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Gln51-Leu183
Tag	N-8His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Human OX40 Ligand is produced by our Mammalian expression system and the target gene encoding Gln51-Leu183 is expressed with a 8His tag at the N-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	7292
UniProt ID	P23510
Synonyms	Tumor necrosis factor ligand superfamily member 4;Glycoprotein Gp34;OX40 ligand;CD252;TAX transcriptionally-activated glycoprotein 1;TXGP1
Summary	OX40L, also known as CD252 is a type II transmembrane glycoprotein that is a member of the tumor necrosis factor (TNF) ligand family. OX40L is expressed on the surface of activated B cells, T cells, dendritic cells, and endothelial cells. It is an essential co-stimulatory molecule that plays an important role in the regulation of T-cell-mediated immunity. OX40L might play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. The interaction of OX40 and OX40L on activated T cells in situ in tumors has been found to facilitate immune responses and subsequent tumor regression.
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction

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