CD14 Humon Recombinant Protein

Specifications

Product Data
Species	Humon
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Thr20-Cys352
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.4
Note	Recombinant Human CD14 is produced by our Mammalian expression system and the target gene encoding Thr20-Cys352 is expressed with a 6His tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	929
UniProt ID	P08571
Synonyms	Monocyte Differentiation Antigen CD14; Myeloid Cell-Specific Leucine-Rich Glycoprotein; CD14
Summary	CD14 is a cell surface glycoprotein that is selectively expressed on monocytes, macrophages, and activated granulocytes. CD14 is a component of the innate immune system. It exists in two forms. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and acts as a pattern recognition receptor that binds lipopolysaccharides (LPS) and various ligands derived from different microbial sources. The binding of CD14 with LPS is catalyzed by LPS binding protein (LBP). Toll-like receptors have also been implicated in the transduction of CD14-LPS signals. Soluble CD14 can be released from the cell surface by phosphatidyinositol-specific phospholipase C and has been found in serum and body fluids. High concentrations of soluble CD14 have been shown to inhibit LPS mediated responses. However, soluble CD14 can also potentiate LPS response in cells that do not express cell surface CD14.
Protein Families	Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Hematopoietic cell lineage, MAPK signaling pathway, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Toll-like receptor signaling pathway

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