Il11 Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Pro22-Leu199
Tag	N-Fc-FLAG
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4
Note	Recombinant Mouse IL-11 (N-Fc) is produced by our Mammalian expression system and the target gene encoding Pro22-Leu199 is expressed with a Fc tag at the N-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	16156
UniProt ID	P47873
Synonyms	Adipogenesis inhibitory factor; AGIF; AGIFoprelvekin; IL11; IL-11; IL-11Oprelvekin; interleukin 11; interleukin-11; Oprelvekin
Summary	Mouse IL-11 is a pleiotropic cytokine that is a part of the IL-6 family and is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, trophoblasts, and other cell types. This cytokine is found in the plasma when inflammation occurs. The types of inflammation can be due to viral infection, cancer, or inflammatory arthritis however, Mouse IL-11 is primarily anti-inflammatory. Mouse IL-11 stimulates hematopoiesis and thrombopoiesis and regulates macrophage differentiation. When synergizing with other cytokines Mouse IL-11 can promote B cell IgG production, protect endothelial cells from oxidative stress, and regulate apoptosis.

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