SIGLEC8 Human Recombinant Protein
CNY 3,140.00
货期*
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Specifications
Product Data | |
Species | Human |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Met17-Ala363
|
Tag | C-6His |
Buffer | Supplied as a 0.2 um filtered solution of PBS, pH7.4 |
Note | Recombinant Human Sialic Acid-binding Ig-like Lectin 8 is produced by our Mammalian expression system and the target gene encoding Met17-Ala363 is expressed with a 6His tag at the C-terminus. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 27181 |
UniProt ID | Q9NYZ4 |
Synonyms | Siglec8; Siglec-8; SAF2; SAF2SAF-2; SAF-2; CD329 antigen; CDw329 |
Summary | Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Siglec-8 is expressed on eosinophils, basophils, and mast cells, and it shows a binding preference for the carbohydrate 6-O sulfated sLex. At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 115 aa cytoplasmic domain with two tyrosine based signaling motifs. Alternative splicing generates additional isoforms that either lack most of the second Ig-like domain or have a substituted cytoplasmic domain without the signaling motifs. |
Protein Families | Druggable Genome, Transmembrane |
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