GAS 6 (GAS6) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Ala31-Ala678
Tag	C-6His
Buffer	Supplied as a 0.2 um filtered solution of PBS, 10% Glycerol , pH7.4.
Note	Recombinant Human Growth Arrest-specific Protein 6 is produced by our Mammalian expression system and the target gene encoding Ala31-Ala678 is expressed with a 6His tag at the C-terminus.
Storage	Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability	12 months from date of despatch
Reference Data
Locus ID	2621
UniProt ID	Q14393
Synonyms	AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; Gas6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6
Summary	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
Protein Families	Druggable Genome, Secreted Protein

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