beta 2 Microglobulin (B2M) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Ile21-Met119&Gly25-Ile308 (Ala269Val)
Tag	C-10His
Buffer	Lyophilized from a 0.2 um filtered solution of 20mM PB, 500mM NaCl, pH7.4.
Note	Recombinant Human B2M&HLA-A is produced by our Mammalian expression system and the target gene encoding Ile21-Met119&Gly25-Ile308 (Ala269Val) is expressed with a 10His tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	567
UniProt ID	P61769
Synonyms	MHC; MY-ESO-1
Summary	NY-ESO-1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. Optimally assembled peptide-HLA-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells.
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Antigen processing and presentation

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