beta 2 Microglobulin (B2M) Human Recombinant Protein
CAT#: TP726739
Recombinant Human HLA-A*0201 NY-ESO-1 complex Protein (C-10His)
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CNY 3,140.00
货期*
2周
规格
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Specifications
Product Data | |
Species | Human |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Ile21-Met119&Gly25-Ile308 (Ala269Val)
|
Tag | C-10His |
Buffer | Lyophilized from a 0.2 um filtered solution of 20mM PB, 500mM NaCl, pH7.4. |
Note | Recombinant Human B2M&HLA-A is produced by our Mammalian expression system and the target gene encoding Ile21-Met119&Gly25-Ile308 (Ala269Val) is expressed with a 10His tag at the C-terminus. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 567 |
UniProt ID | P61769 |
Synonyms | MHC; MY-ESO-1 |
Summary | NY-ESO-1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. Optimally assembled peptide-HLA-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Antigen processing and presentation |
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