Noggin (NOG) Human Recombinant Protein

CAT#: TP727069

Recombinant Human Noggin/NOG



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CNY 3,140.00


货期*
2周

规格
    • 10 ug

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    • 100 ul

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Specifications

Product Data
Species Human
Protein Source Human
Expression cDNA Clone or AA Sequence
Buffer Lyophilized from a 0.2 um filtered solution of 20mM PB, 500mM NaCl, 2mM EDTA, pH 7.4.
Note Recombinant Human Noggin is produced by our expression system and the target gene encoding Gln28-Cys232 is expressed
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Locus ID 9241
UniProt ID Q13253
Synonyms Noggin; NOG
Summary Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Mature Human Noggin contains an N-terminal acidic region, a central basic heparin-binding segment and a C-terminal cysteine-knot structure. Noggin is very highly conserved among vertebrates, such that mature human Noggin shares 99%, 99%, 98%, 97% and 89% aa sequence identity with mouse, rat bovine, equine and chicken Noggin, respectively. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds some BMPs such as BMP4 with high affinity and others such as BMP7 with lower affinity. It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors. Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin.
Protein Families Druggable Genome, Secreted Protein
Protein Pathways TGF-beta signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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