CD161 (KLRB1) Human Recombinant Protein

CAT#: TP727276

Recombinant Human KLRB1/CD161 (C-Fc)



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CNY 3,140.00


货期*
2周

规格
    • 10 ug

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经常一起买 (1)
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Specifications

Product Data
Species Human
Protein Source Human
Expression cDNA Clone or AA Sequence
Tag C-Fc
Buffer Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Note Recombinant Human Killer cell lectin-like receptor subfamily B member 1 is produced by our Mammalian expression system and the target gene encoding Gln67-Ser225 is expressed with a Fc tag at the C-terminus.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Locus ID 3820
UniProt ID Q12918
Synonyms Killer cell lectin-like receptor subfamily B member 1;KLRB1;CLEC5B; NKRP1A;CD161;Natural killer cell surface protein P1A;NKR-P1A;HNKR-P1a;C-type lectin domain family 5 member B;KLRB1
Summary Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Protein Families Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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