Il23r Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Gly24-Asp372
Tag	C-Fc
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Note	Recombinant Mouse Interleukin-23 Receptor is produced by our Mammalian expression system and the target gene encoding Gly24-Asp372 is expressed with a Fc tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	209590
UniProt ID	Q8K4B4
Synonyms	Interleukin-23 receptor; Il23r; IL-23 receptor; IL-23R; interleukin 23 receptor
Summary	Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.

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