Troponin C1 (TNNC1) Human Recombinant Protein

CAT#: TP727615

Recombinant Human Troponin C/TN-C/TNNC1(N-6His)



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CNY 3,140.00


货期*
2周

规格
    • 10 ug

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经常一起买 (1)
TNNC1 mouse monoclonal antibody, clone OTI5H3 (formerly 5H3)
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Species Human
Protein Source E. coli
Expression cDNA Clone or AA Sequence
Tag N-His
Buffer Supplied as a 0.2 um filtered solution of 20mM Tris,100mM NaCl,1mM DTT,10% Glycerol,pH 8.0.
Note Recombinant Human slow skeletal and cardiac muscles is produced by our E.coli expression system and the target gene encoding Met1-Glu161 is expressed with a 6His tag at the N-terminus.
Storage Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability 12 months from date of despatch
Reference Data
Locus ID 7134
UniProt ID P63316
Synonyms CMH7; TNNC1; TNNI3; Troponin I
Summary Troponin I, also known as TNI, is a 24 kDa component of a protein complex on striated muscle thin filaments.Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Troponin I inhibits the calcium-dependent muscle contraction mediated by Troponins C and T. The expression of cardiac Troponin I (TNNI3) is restricted to cardiac muscle, while TNNI1 and TNNI2 (encoded by distinct genes) are expressed in skeletal muscle. Mutations of cardiac Troponin I are associated with heriditary cardiomyopathy. Human cardiac Troponin I shares 93% amino acid sequence identity with mouse and rat cardiac Troponin I.
Protein Pathways Calcium signaling pathway, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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