Methionine Aminopeptidase 2 (METAP2) Human Recombinant Protein

CAT#: TP727718

Recombinant Human Methionine Aminopeptidase 2/METAP2 (N-6His)



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CNY 3,140.00


货期*
2周

规格
    • 10 ug

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经常一起买 (1)
METAP2 (Methionine Aminopeptidase 2) mouse monoclonal antibody, clone OTI1F6 (formerly 1F6)
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Species Human
Protein Source Baculovirus
Expression cDNA Clone or AA Sequence
Tag N-His
Buffer Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, pH 8.0 .
Note Recombinant Human Methionine Aminopeptidase 2 is produced by our Baculovirus expression system and the target gene encoding Ala2-Tyr478 is expressed with a 6His tag at the N-terminus.
Storage Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability 12 months from date of despatch
Reference Data
Locus ID 10988
UniProt ID P50579
Synonyms Methionine aminopeptidase 2; MAP 2; MetAP 2; p67; p67eIF2; Peptidase M; METAP2; MAP2
Summary Human Methionine Aminopeptidase 2 (METAP2, MAP2) is a member of the M24 family of metalloproteases. METAPs catalyze the removal of the initiator methionine residue from nascent peptides and are essential for cell growth. MAP2 binds 2 cobalt or manganese ions and contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. It is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation. METAP2 plays an important role in the development of different types of cancer and has been a novel target for developing anti-cancer drugs. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amno-terminal methionine residue from nascent protein. MAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. It also plays a critical role in the regulation of protein synthesis.
Protein Families Druggable Genome, Protease
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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