CD19 Cynomolgus Recombinant Protein
CAT#: TP727838
Recombinant Cynomolgus CD19/CD19 Molecule (C-Fc)
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CNY 3,140.00
货期*
2周
规格
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Specifications
Product Data | |
Species | Cynomolgus |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Pro20-Lys292
|
Tag | C-Fc |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS,pH7.4. |
Note | Recombinant Rhesus macaque CD19 molecule is produced by our Mammalian expression system and the target gene encoding Pro20-Lys292 is expressed with a Fc tag at the C-terminus. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 705211 |
UniProt ID | F7F486 |
Synonyms | B-Lymphocyte Antigen CD19; B-Lymphocyte Surface Antigen B4; Differentiation Antigen CD19; T-Cell Surface Antigen Leu-12; CD19 |
Summary | CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. |
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