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Constitutive androstane receptor (NR1I3) (NM_001077482) Human Recombinant Protein
CAT＃: TP760789
Purified recombinant protein of Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug
View other "Constitutive androstane receptor" proteins (29)
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CNY 2,040.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length NR1I3
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| Tag | N-His |
| Predicted MW | 40.3 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_001070950 |
| Locus ID | 9970 |
| UniProt ID | Q14994 |
| Refseq Size | 1408 |
| Cytogenetics | 1q23.3 |
| Refseq ORF | 1071 |
| Synonyms | CAR; CAR1; MB67 |
| Summary | This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020] |
| Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
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Resources
| 蛋白相关资源 |
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC417512 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
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| LC421424 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421425 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421426 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421427 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421428 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421430 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421431 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421432 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421433 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421434 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421436 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421437 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC425856 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC425868 | NR1I3 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY417512 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 3 |
CNY 3,080.00 |
|
| LY421424 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 6 |
CNY 3,080.00 |
|
| LY421425 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 11 |
CNY 3,080.00 |
|
| LY421426 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 5 |
CNY 3,080.00 |
|
| LY421427 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 9 |
CNY 3,080.00 |
|
| LY421428 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 12 |
CNY 3,080.00 |
|
| LY421430 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 15 |
CNY 3,080.00 |
|
| LY421431 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 13 |
CNY 3,080.00 |
|
| LY421432 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 14 |
CNY 3,080.00 |
|
| LY421433 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 7 |
CNY 3,080.00 |
|
| LY421434 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 10 |
CNY 3,080.00 |
|
| LY421436 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 4 |
CNY 3,080.00 |
|
| LY421437 | Transient overexpression lysate of nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1 |
CNY 3,080.00 |
|
| TP760687 | Purified recombinant protein of Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 8, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug |
CNY 2,040.00 |
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