LAMTOR1 (NM_017907) Human Recombinant Protein
CAT#: TP762012
Purified recombinant protein of Human late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (LAMTOR1),Gly2–Pro161, with N-terminal His-PDCD1(Pro21-Val170) tag, expressed in E. coli, 50ug
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CNY 2,050.00
货期*
现货
规格
经常一起买 (1)
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding the region(Gly2–Pro161) of LAMTOR1
|
Tag | N-His PDCD1(Pro21-Val170) |
Predicted MW | 34.4 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_060377 |
Locus ID | 55004 |
UniProt ID | Q6IAA8 |
Refseq Size | 1198 |
Cytogenetics | 11q13.4 |
Refseq ORF | 483 |
Synonyms | C11orf59; p18; p27RF-Rho; PDRO; Ragulator1 |
Summary | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.[UniProtKB/Swiss-Prot Function] |
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