LAMTOR1 (NM_017907) Human Recombinant Protein

CAT#: TP762012

Purified recombinant protein of Human late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (LAMTOR1),Gly2–Pro161, with N-terminal His-PDCD1(Pro21-Val170) tag, expressed in E. coli, 50ug



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CNY 2,050.00


货期*
现货

规格
    • 50 ug

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经常一起买 (1)
LAMTOR1 Rabbit polyclonal Antibody
    • 100 ul

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(Gly2–Pro161) of LAMTOR1
Tag N-His PDCD1(Pro21-Val170)
Predicted MW 34.4 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_060377
Locus ID 55004
UniProt ID Q6IAA8
Refseq Size 1198
Cytogenetics 11q13.4
Refseq ORF 483
Synonyms C11orf59; p18; p27RF-Rho; PDRO; Ragulator1
Summary As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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