Histone acetyltransferase MYST3 (KAT6A) Human shRNA Plasmid Kit (Locus ID 7994)
CAT#: TL311283
KAT6A - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
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CNY 5,740.00
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现货
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Specifications
Product Data | |
Product Name | Histone acetyltransferase MYST3 (KAT6A) Human shRNA Plasmid Kit (Locus ID 7994) |
Locus ID | 7994 |
UniProt ID | Q92794 |
Synonyms | MOZ; MRD32; MYST3; RUNXBP2; ZC2HC6A; ZNF220 |
Vector | pGFP-C-shLenti |
Format | Lentiviral plasmids |
Kit Components | KAT6A - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 7994). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
RefSeq | NM_001099412, NM_001099413, NM_006766, NM_001305878, NM_001099413.1, NM_001099412.1, NM_006766.1, NM_006766.2, NM_006766.3, NM_006766.4, BC018011, BC142659, BC142959, BC172379, NM_006766.5 |
Summary | This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
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