Nedd4l Rat shRNA Plasmid (Locus ID 291553)
CAT#: TL700973
Nedd4l - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
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CNY 7,740.00
货期*
2周
规格
Cited in 2 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Product Name | Nedd4l Rat shRNA Plasmid (Locus ID 291553) |
Locus ID | 291553 |
Synonyms | Nedd4-2 |
Vector | pGFP-C-shLenti |
Format | Lentiviral plasmids |
Kit Components | Nedd4l - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 291553). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
RefSeq | NM_001008300, NM_001008300.1, NM_001008300.2, BC061798, BC086371 |
Summary | mouse homolog appears to be involved in binding and regulating the amiloride-sensitive epithelial sodium channel which plays a role in sodium homeostasis and control of blood volume and blood pressure [RGD, Feb 2006] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (2)
The use of this RNAi has been cited in the following citations: |
---|
E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
,null,
Nature Communications
,PubMed ID 33608556
[Nedd4l]
|
Mutations in the HECT domain of NEDD4L lead to AKT/mTOR pathway deregulation and cause periventricular nodular heterotopia
,null,
Nature genetics
,PubMed ID 27694961
[Nedd4l]
|
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