HIF1 beta (ARNT) Human siRNA Oligo Duplex (Locus ID 405)
CAT#: SR300295
ARNT (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 3 publications. |
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经常一起买 (3)
ARNT (HIF1 beta) mouse monoclonal antibody, clone OTI1A1 (formerly 1A1)
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001197325, NM_001286035, NM_001286036, NM_001668, NM_178426, NM_178427, NM_001350224, NM_001350225, NM_001350226 |
Synonyms | bHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO |
Components | ARNT (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 405)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (3)
The use of this RNAi has been cited in the following citations: |
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Hypoxia-inducible factor-1 promotes cancer progression through activating AKT/Cyclin D1 signaling pathway in osteosarcoma
,Zhang, B;Li, YL;Zhao, JL;Zhen, O;Yu, C;Yang, BH;Yu, XR;,
Biomed. Pharmacother.
,PubMed ID 29807229
[ARNT]
|
Defining the role of oxygen tension in human neural progenitor fate
,Xie, Y;Zhang, J;Lin, Y;Gaeta, X;Meng, X;Wisidagama, DR;Cinkornpumin, J;Koehler, CM;Malone, CS;Teitell, MA;Lowry, WE;,
Stem Cell Reports
,PubMed ID 25418722
[ARNT]
|
Hypoxia Inducible Regulation of Placental BOK Expression
,Luo, D;Caniggia, I;Post, M;,
Biochem. J.
,PubMed ID 24806028
[ARNT]
|
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