Integrin beta 4 (ITGB4) Human siRNA Oligo Duplex (Locus ID 3691)
CAT#: SR302473
ITGB4 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 3 publications. |
Product images
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_000213, NM_001005619, NM_001005731, NM_001321123 |
Synonyms | CD104; GP150 |
Components | ITGB4 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 3691)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (3)
The use of this RNAi has been cited in the following citations: |
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Erratum: A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer
,Mohanty, A;Nam, A;Pozhitkov, A;Yang, L;Srivastava, S;Nathan, A;Wu, X;Mambetsariev, I;Nelson, M;Subbalakshmi, AR;Guo, L;Arvanitis, LD;Nasser, MW;Batra, SK;Orban, J;Jolly, MK;Massarelli, E;Kulkarni, P;Salgia, R;,
iScience
,PubMed ID 33134900
[ITGB4]
|
A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer
,Mohanty, A;Nam, A;Pozhitkov, A;Yang, L;Srivastava, S;Nathan, A;Wu, X;Mambetsariev, I;Nelson, M;Subbalakshmi, A;Guo, L;Nasser, M;Batra, S;Orban, J;Jolly, M;Massarelli, E;Kulkarni, P;Salgia, R;,
iScience
,PubMed ID 32947124
[ITGB4]
|
A Non-genetic Mechanism for Chemoresistance in Lung Cancer: The Role of Integrin β4/Paxillin Axis
,Mohanty, A;Nam, A;Pozhitkov, A;Bhattacharya, S;,
bioRxiv
[ITGB4]
|
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