Legumain (LGMN) Human siRNA Oligo Duplex (Locus ID 5641)
CAT#: SR303790
LGMN (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 2 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001008530, NM_005606, NM_001363699, NM_001363696 |
Synonyms | AEP; LGMN1; PRSC1 |
Components | LGMN (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 5641)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (2)
The use of this RNAi has been cited in the following citations: |
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Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer/'s disease
,Zhang, Z;Song, M;Liu, X;Kang, SS;Duong, DM;,
NATURE COMMUNICATIONS
,PubMed ID 26549211
[LGMN]
|
Local mitochondrial-endolysosomal microfusion cleaves the voltage-dependent anion channel 1 to promote survival in hypoxia
,Brahimi-Horn, MC;Lacas-Gervais, S;Adaixo, R;Ilc, K;Rouleau, M;Notte, A;Dieu, M;Michels, C;Voeltzel, T;Maguer-Satta, V;Pelletier, J;Ilie, M;Hofman, P;Manoury, B;Schmidt, A;Hiller, S;Pouysségur, J;Mazure, NM;,
Mol. Cell. Biol.
,PubMed ID 25691661
[LGMN]
|
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