Rad51L1 (RAD51B) Human siRNA Oligo Duplex (Locus ID 5890)
CAT#: SR303968
RAD51B (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 1 publication. |
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RAD51L1 mouse monoclonal antibody, clone OTI7H4 (formerly 7H4)
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Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_002877, NM_133509, NM_133510, NM_001321809, NM_001321810, NM_001321812, NM_001321814, NM_001321815, NM_001321817, NM_001321818, NM_001321819, NM_001321821 |
Synonyms | R51H2; RAD51L1; REC2 |
Components | RAD51B (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 5890)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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Fallopian tube precursor lesions of serous ovarian carcinoma require L1CAM for dissemination and metastasis
,Doberstein, K;Spivak, R;Feng, Y;Stuckelberger, S;Mills, G;Devins, K;Schwartz, L;Iwanicki, M;Fogel, M;Altevogt, P;Drapkin, R;,
bioRxiv
[RAD51B]
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