EGFR Human siRNA Oligo Duplex (Locus ID 1956)
CAT#: SR320009
EGFR (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR320009 is the updated version of SR301357.
CNY 4,090.00
货期*
4周
规格
Cited in 3 publications. |
Product images
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_005228, NM_201282, NM_201283, NM_201284, NM_001346897, NM_001346898, NM_001346899, NM_001346900, NM_001346941 |
Synonyms | ERBB; ERBB1; ERRP; HER1; mENA; NISBD2; PIG61 |
Components | EGFR (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 1956)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (3)
The use of this RNAi has been cited in the following citations: |
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EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer
,Rose, M;Maurer, A;Wirtz, J;Bleilevens, A;Waldmann, T;Wenz, M;Eyll, M;Geelvink, M;Gereitzig, M;Rüchel, N;Denecke, B;Eltze, E;Herrmann, E;Toma, M;Horst, D;Grimm, T;Denzinger, S;Ecke, T;Vögeli, TA;Knuechel, R;Maurer, J;Gaisa, NT;,
Oncogene
,PubMed ID 32978523
[EGFR]
|
Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo
,Kozielski, KL;Ruiz-Valls, A;Tzeng, SY;Guerrero-Cázares, H;Rui, Y;Li, Y;Vaughan, HJ;Gionet-Gonzales, M;Vantucci, C;Kim, J;Schiapparelli, P;Al-Kharboosh, R;Quiñones-Hinojosa, A;Green, JJ;,
Biomaterials
,PubMed ID 31026613
[EGFR]
|
MiR-615 inhibits cell proliferation, migration and invasion by targeting EGFR in human glioblastoma
,Ji, Y;Sun, Q;Zhang, J;Hu, H;,
Biochem. Biophys. Res. Commun.
,PubMed ID 29605294
[EGFR]
|
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