SRC Human siRNA Oligo Duplex (Locus ID 6714)
CAT#: SR321884
SRC (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR321884 is the updated version of SR304574.
CNY 4,090.00
货期*
4周
规格
Cited in 4 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_005417, NM_198291 |
Synonyms | ASV; c-SRC; p60-Src; SRC1; THC6 |
Components | SRC (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 6714)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (4)
The use of this RNAi has been cited in the following citations: |
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PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC
,Davis, TB;Yang, M;Wang, H;Lee, C;Yeatman, TJ;Pledger, WJ;,
Oncotarget
,PubMed ID 31827720
[SRC]
|
SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC
,Zhang, S;Yang, Z;Bao, W;Liu, L;You, Y;Wang, X;Shao, L;Fu, W;Kou, X;Shen, W;Yuan, C;Hu, B;Dang, W;Nandakumar, KS;Jiang, H;Zheng, M;Shen, X;,
Autophagy
,PubMed ID 31208298
[SRC]
|
MicroRNA-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer
,null,
Cancer research
,PubMed ID 23074286
[SRC]
|
MicroRNA-205 inhibits Src-mediated oncogenic pathways in renal cancer
,null,
Cancer research
,PubMed ID 21330408
[SRC]
|
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