ADAM17 Human siRNA Oligo Duplex (Locus ID 6868)
CAT#: SR321951
ADAM17 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR321951 is the updated version of SR304689.
CNY 4,090.00
货期*
5周
规格
Cited in 51 publications. |
Product images
经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_003183, NM_021832 |
Synonyms | ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE |
Components | ADAM17 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 6868)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2020] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (51)
The use of this RNAi has been cited in the following citations: |
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CD36 promotes vasculogenic mimicry in melanoma by mediating adhesion to the extracellular matrix
,null,
BMC Cancer
,PubMed ID 34215227
[ADAM17]
|
Receptor-Interacting Protein 140 Enhanced Temozolomide-Induced Cellular Apoptosis Through Regulation of E2F1 in Human Glioma Cell Lines.
,null,
Neuromolecular medicine
,PubMed ID 34075570
[ADAM17]
|
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
,null,
Nature Communications
,PubMed ID 33953160
[ADAM17]
|
Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5′-deoxy-5-fluorocytidine (5′-DFCR)
,null,
Journal of Experimental & Clinical Cancer Research : CR
,PubMed ID 33874986
[ADAM17]
|
Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling
,null,
Aging Cell
,PubMed ID 33166073
[ADAM17]
|
Differential regulation of a placental Sam68 and sFlt-1 gene pathway and the relevance to maternal vitamin D sufficiency
,null,
Pregnancy hypertension
,PubMed ID 33068876
[ADAM17]
|
LRP1 receptor-mediated immunosuppression of α-MMC on monocytes.
,null,
International immunopharmacology
,PubMed ID 30785094
[ADAM17]
|
Cross-linking Proteomics Indicates Effects of Simvastatin on the TLR2 Interactome and Reveals ACTR1A as a Novel Regulator of the TLR2 Signal Cascade *
,null,
Molecular & Cellular Proteomics : MCP
,PubMed ID 31221720
[ADAM17]
|
Nkx2–5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation
,null,
Scientific Reports
,PubMed ID 30742009
[ADAM17]
|
The role of R-spondin 1 through activating Wnt/β-catenin in the growth, survival and migration of ovarian cancer cells.
,null,
Gene
,PubMed ID 30572097
[ADAM17]
|
Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy
,null,
Autophagy
,PubMed ID 30289335
[ADAM17]
|
Perturbations of Neuron-Restrictive Silencing Factor Modulate Corticotropin-Releasing Hormone Gene Expression in the Human Cell Line BeWo
,null,
Molecular Neuropsychiatry
,PubMed ID 30397598
[ADAM17]
|
CXCL9 promotes the progression of diffuse large B-cell lymphoma through up-regulating β-catenin.
,null,
Biomedicine pharmacotherapy = Biomedecine pharmacotherapie
,PubMed ID 30130730
[ADAM17]
|
Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A 2 and mediates its toxic activity
,null,
Scientific Reports
,PubMed ID 30006575
[ADAM17]
|
Vascular Biology and Microcirculation: KLF2-mediated disruption of PPAR-γ signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow
,null,
American Journal of Physiology - Heart and Circulatory Physiology
,PubMed ID 29631374
[ADAM17]
|
Drug delivery using polyhistidine peptide-modified liposomes that target endogenous lysosome.
,null,
Biochemical and biophysical research communications
,PubMed ID 29746864
[ADAM17]
|
Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone
,null,
The Journal of Biological Chemistry
,PubMed ID 29523683
[ADAM17]
|
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein kinase (DMPK)1 as a novel angiogenesis target
,null,
Oncotarget
,PubMed ID 29296234
[ADAM17]
|
Estrogen induced expression of tissue factor pathway inhibitor-2 in MCF7 cells involves lysine-specific demethylase 1.
,null,
Molecular and cellular endocrinology
,PubMed ID 28088469
[ADAM17]
|
CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells.
,null,
Cancer letters
,PubMed ID 29024811
[ADAM17]
|
Insulin promotes cell migration by regulating PSA-NCAM.
,null,
Experimental cell research
,PubMed ID 28341445
[ADAM17]
|
Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6
,null,
Hormones & Cancer
,PubMed ID 28516379
[ADAM17]
|
Altered Protein Interactions of the Endogenous Interactome of PTPIP51 towards MAPK Signaling
,null,
Biomolecules
,PubMed ID 28754031
[ADAM17]
|
Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation.
,null,
Toxicology
,PubMed ID 27262837
[ADAM17]
|
Transcriptome-wide analysis of alternative RNA splicing events in Epstein-Barr virus-associated gastric carcinomas
,null,
PLoS ONE
,PubMed ID 28493890
[ADAM17]
|
Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival
,null,
Oncotarget
,PubMed ID 27494851
[ADAM17]
|
Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation
,null,
Scientific Reports
,PubMed ID 27334688
[ADAM17]
|
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells
,null,
Journal of cellular biochemistry
,PubMed ID 25808624
[ADAM17]
|
Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor
,null,
PLoS ONE
,PubMed ID 27171436
[ADAM17]
|
Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma
,null,
International journal of cancer
,PubMed ID 25307878
[ADAM17]
|
HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS
,null,
Journal of Neuroinflammation
,PubMed ID 26934876
[ADAM17]
|
Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer
,null,
Nature Communications
,PubMed ID 26924072
[ADAM17]
|
PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer
,null,
EBioMedicine
,PubMed ID 26844273
[ADAM17]
|
Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma
,null,
Molecular Cancer
,PubMed ID 26472042
[ADAM17]
|
Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O 6 -methylguanine DNA-methyltransferase, in breast cancer cells
,null,
Scientific Reports
,PubMed ID 26420420
[ADAM17]
|
Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism
,null,
Oncotarget
,PubMed ID 25839160
[ADAM17]
|
Lysine biotinylation and methionine oxidation in the heat shock protein HSP60 synergize in the elimination of reactive oxygen species in human cell cultures
,null,
The Journal of nutritional biochemistry
,PubMed ID 24582286
[ADAM17]
|
p38MAPK Signaling Enhances Glycolysis Through the Up-Regulation of the Glucose Transporter GLUT-4 in Gastric Cancer Cells.
,null,
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
,PubMed ID 25925563
[ADAM17]
|
ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling
,null,
Scientific Reports
,PubMed ID 25773070
[ADAM17]
|
Acute hantavirus infection induces galectin-3-binding protein.
,null,
The Journal of general virology
,PubMed ID 25013204
[ADAM17]
|
Tumor necrosis-initiated complement activation stimulates proliferation of medulloblastoma cells
,null,
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
,PubMed ID 25603857
[ADAM17]
|
Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase–phosphoinositide 3-kinase-dependent anti-apoptotic signaling
,null,
Cancer Science
,PubMed ID 25287946
[ADAM17]
|
Resveratrol Enhances Palmitate-Induced ER Stress and Apoptosis in Cancer Cells
,null,
PLoS ONE
,PubMed ID 25436452
[ADAM17]
|
Holocarboxylasesynthetase interacts physically with euchromatic histone-lysine N-methyltransferase, linking histone biotinylation with methylation events
,null,
The Journal of nutritional biochemistry
,PubMed ID 23337344
[ADAM17]
|
Estrogen Regulation of Anti-Apoptotic Bcl-2 Family Member Mcl-1 Expression in Breast Cancer Cells
,null,
PLoS ONE
,PubMed ID 24971890
[ADAM17]
|
IMP1 promotes choriocarcinoma cell migration and invasion through the novel effectors RSK2 and PPME1.
,null,
Gynecologic oncology
,PubMed ID 23911878
[ADAM17]
|
A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng
,null,
PLoS ONE
,PubMed ID 24130681
[ADAM17]
|
Disorders with similar clinical phenotypes reveal underlying genetic interaction: SATB2 acts as an activator of the UPF3B gene
,null,
Human genetics
,PubMed ID 23925499
[ADAM17]
|
The Induction of microRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a p53-Dependent Cell Cycle Arrest
,null,
PLoS ONE
,PubMed ID 23308284
[ADAM17]
|
n-Butyl Benzyl Phthalate Promotes Breast Cancer Progression by Inducing Expression of Lymphoid Enhancer Factor 1
,null,
PLoS ONE
,PubMed ID 22905168
[ADAM17]
|
Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity.
,null,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
,PubMed ID 22189971
[ADAM17]
|
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