YAP1 Human siRNA Oligo Duplex (Locus ID 10413)
CAT#: SR323110
YAP1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR323110 is the updated version of SR307060.
CNY 4,090.00
货期*
4周
规格
Cited in 6 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001130145, NM_001195044, NM_001195045, NM_001282097, NM_001282098, NM_001282099, NM_001282100, NM_001282101, NM_006106 |
Synonyms | COB1; YAP; YAP2; YAP65; YKI |
Components | YAP1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 10413)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (6)
The use of this RNAi has been cited in the following citations: |
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Role of Hippo/YAP signaling in irradiation-induced glioma cell apoptosis
,Xu, X;Chen, Y;Wang, X;Mu, X;,
Cancer Manag Res
,PubMed ID 31496812
[YAP1]
|
Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo
,Kozielski, KL;Ruiz-Valls, A;Tzeng, SY;Guerrero-Cázares, H;Rui, Y;Li, Y;Vaughan, HJ;Gionet-Gonzales, M;Vantucci, C;Kim, J;Schiapparelli, P;Al-Kharboosh, R;Quiñones-Hinojosa, A;Green, JJ;,
Biomaterials
,PubMed ID 31026613
[YAP1]
|
Spliceosome-associated factor catenin b-like 1 accelerates ovarian cancer progression by inducing expression and nuclear accumulation of yes-associated protein
,Li, X;Liu, S;,
Int J Clin Exp Med
[YAP1]
|
ROCK Inhibitor Y27632 Induced Morphological Shift and Enhanced Neurite Outgrowth-Promoting Property of Olfactory Ensheathing Cells via YAP-Dependent Up-Regulation of L1-CAM
,Li, Y;Huo, S;Fang, Y;Zou, T;Gu, X;Tao, Q;Xu, H;,
Front. Cell. Neurosci.
,PubMed ID 30618636
[YAP1]
|
COPB2 promotes cell proliferation and tumorigenesis through up-regulating YAP1 expression in lung adenocarcinoma cells
,Pu, X;Wang, J;Li, W;Fan, W;Wang, L;Mao, Y;Yang, S;Liu, S;Xu, J;Lv, Z;Xu, L;Shu, Y;,
Biomed. Pharmacother.
,PubMed ID 29674272
[YAP1]
|
Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells
,null,
Stem Cell Reports
,PubMed ID 26028530
[YAP1]
|
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