SIK3 Human siRNA Oligo Duplex (Locus ID 23387)
CAT#: SR323570
SIK3 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR323570 is the updated version of SR308237.
CNY 4,090.00
货期*
4周
规格
Cited in 1 publication. |
Product images
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001281748, NM_001281749, NM_025164, NM_001366686, NM_001366687 |
Synonyms | L19; QSK; SEMDK; SIK-3 |
Components | SIK3 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 23387)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).[UniProtKB/Swiss-Prot Function] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling
,Csukasi, F;Duran, I;Barad, M;Barta, T;Gudernova, I;Trantirek, L;Martin, JH;Kuo, CY;Woods, J;Lee, H;Cohn, DH;Krejci, P;Krakow, D;,
Sci Transl Med
,PubMed ID 30232230
[SIK3]
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