Zeb1 Mouse siRNA Oligo Duplex (Locus ID 21417)
CAT#: SR422122
Zeb1 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 2 publications. |
Product images
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经常一起买 (2)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_011546, NM_001360981, NM_001360982 |
Synonyms | 3110032K11Rik; AREB6; BZP; MEB1; Nil2; TCF-8; Tcf8; Tcf18; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha |
Components | Zeb1 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 21417)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1 (By similarity). Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.[UniProtKB/Swiss-Prot Function] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (2)
The use of this RNAi has been cited in the following citations: |
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A genetic cell context-dependent role for ZEB1 in lung cancer
,Zhang, T;Guo, L;Creighton, CJ;Lu, Q;Gibbons, DL;Yi, ES;Deng, B;Molina, JR;Sun, Z;Yang, P;Yang, Y;,
Nat Commun
,PubMed ID 27456471
[Zeb1]
|
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
,Chen, L;Gibbons, DL;Goswami, S;Cortez, MA;Ahn, YH;Byers, LA;Zhang, X;Yi, X;Dwyer, D;Lin, W;Diao, L;Wang, J;Roybal, JD;Patel, M;Ungewiss, C;Peng, D;Antonia, S;Mediavilla-Varela, M;Robertson, G;Jones, S;Suraokar, M;Welsh, JW;Erez, B;Wistuba, II;Chen, L;Peng,
Nat Commun
,PubMed ID 25348003
[Zeb1]
|
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