Trip4 Mouse siRNA Oligo Duplex (Locus ID 56404)
CAT#: SR427213
Trip4 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR427213 is the updated version of SR417727.
CNY 4,090.00
货期*
4周
规格
Cited in 1 publication. |
Product images
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经常一起买 (2)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001170907, NM_019797, NM_001357872 |
Synonyms | 4930558E03Rik; ASC-1; Asc1; BB191711 |
Components | Trip4 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 56404)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (By similarity). Also involved in androgen receptor transactivation (PubMed:12077347). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction (By similarity). May play a role in late myogenic differentiation (PubMed:27008887).[UniProtKB/Swiss-Prot Function] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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ASC-1 Is a Cell Cycle Regulator Associated with Severe and Mild Forms of Myopathy
,Villar-Quiles, RN;Catervi, F;Cabet, E;Juntas-Morales, R;Genetti, CA;Gidaro, T;Koparir, A;Yüksel, A;Coppens, S;Deconinck, N;Pierce-Hoffman, E;Lornage, X;Durigneux, J;Laporte, J;Rendu, J;Romero, NB;Beggs, AH;Servais, L;Cossée, M;Olivé, M;Böhm, J;Duband-Goulet, I;Ferreiro, A;,
Ann. Neurol.
,PubMed ID 31794073
[TRIP4]
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