SIRPG Mouse Monoclonal Antibody [Clone ID: OX119]

Specifications

Product Data
Clone Name	OX119
Applications	FC, IP
Recommend Dilution	Flow Cytometry: 1/50 - 1/200. Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Immunoprecipitation.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant SIRPgamma.CD4.
Specificity	This antibody recognises SIRP gamma, a 55kD signal regulatory protein which is a member of the immunoglobulin gene superfamily. Spleen cells from immunised BALB/c mice were fused with cells of the NS-1 myeloma cell line.
Formulation	Phosphate buffered saline pH7.4 containing 0.09% Sodium Azide (NaN3) State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein G from tissue culture supernatant
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	signal regulatory protein gamma
Database Link	Entrez Gene 55423 Human UniProt ID Q9P1W8
Background	SIRP gamma, also known as CD172g, is expressed on most T lymphocytes and a subset of B-cells but is absent on myeloid cells. CD172g has a truncated cytoplasmic tail, which is similar to SIRP beta, but unlike SIRP beta CD172g does not require DAP12 for expression at the cell surface. CD172g, like SIRP alpha, binds to CD47 inducing apoptosis. It is also involved in the negative regulation of receptor tyrosine kinase-coupled signalling.
Synonyms	SIRP-beta-2, SIRP-b2, SIRPB2, SIRP gamma
Reference Data

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