CD5 Mouse Monoclonal Antibody [Clone ID: L17F12]
CAT#: AM26700BT-N
CD5 mouse monoclonal antibody, clone L17F12, Biotin
Conjugation: Unconjugated APC FITC PE
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CNY 3,810.00
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Specifications
Product Data | |
Clone Name | L17F12 |
Applications | FC |
Recommend Dilution | Indirect Immunofluorescence analysis by Flow cytometry. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human acute lymphoblastic leukemia (ALL) T cells |
Specificity | This antibody reacts with CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B lymphocytes subset (B-1a lymphocytes). |
Formulation | Phosphate buffered saline (PBS) Label: Biotin State: Liquid purified Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4 Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin. |
Concentration | lot specific |
Conjugation | Biotin |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | CD5 molecule |
Database Link | |
Background | CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. |
Synonyms | CD5, LEU1 |
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