CD5 Mouse Monoclonal Antibody [Clone ID: L17F12]

CAT#: AM26700BT-N

CD5 mouse monoclonal antibody, clone L17F12, Biotin

Conjugation: Unconjugated APC Biotin FITC PE



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CNY 3,810.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name L17F12
Applications FC
Recommend Dilution Indirect Immunofluorescence analysis by Flow cytometry.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Human acute lymphoblastic leukemia (ALL) T cells
Specificity This antibody reacts with CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B lymphocytes subset (B-1a lymphocytes).
Formulation Phosphate buffered saline (PBS)
Label: Biotin
State: Liquid purified Ig fraction
Preservative: 15 mM sodium azide, approx. pH 7.4
Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration lot specific
Conjugation Biotin
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
Gene Name CD5 molecule
Background CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.
The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.
Synonyms CD5, LEU1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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