Aurora C (AURKC) Mouse Monoclonal Antibody [Clone ID: OTI10A7]

Specifications

Product Data
Clone Name	OTI10A7
Applications	IF, WB
Recommend Dilution	WB 1:500, IF 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human AURKC expression vector
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	35.6 kDa
Gene Name	aurora kinase C
Database Link	NP_001015878 Entrez Gene 6795 Human UniProt ID Q9UQB9
Background	This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
Synonyms	AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90; SPGF5; STK13
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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