Acid sphingomyelinase (SMPD1) Mouse Monoclonal Antibody [Clone ID: OTI10C5]

Specifications

Product Data
Clone Name	OTI10C5
Applications	WB
Recommend Dilution	WB 1:200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 62-341 of human SMPD1 (NP_000534) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	65 kDa
Gene Name	sphingomyelin phosphodiesterase 1
Database Link	NP_000534 Entrez Gene 6609 Human UniProt ID P17405
Background	The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]
Synonyms	ASM; ASMASE; NPD
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Lysosome, Metabolic pathways, Sphingolipid metabolism

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