Acid sphingomyelinase (SMPD1) Mouse Monoclonal Antibody [Clone ID: OTI10C5]

Specifications

Product Data
Clone Name	OTI10C5
Applications	WB
Recommend Dilution	WB 1:200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 62-341 of human SMPD1 (NP_000534) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	65 kDa
Gene Name	sphingomyelin phosphodiesterase 1
Database Link	NP_000534 Entrez Gene 6609 Human UniProt ID P17405
Background	The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]
Synonyms	ASM; ASMASE; NPD
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Lysosome, Metabolic pathways, Sphingolipid metabolism

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