B7-1 (CD80) Mouse Monoclonal Antibody [Clone ID: MEM-233]

CAT#: SM1742P

B7-1 (CD80) mouse monoclonal antibody, clone MEM-233, Purified

Size: 100 ug 200 ug

Conjugation: Unconjugated FITC



Need it in bulk or conjugated?
Get a free quote

CNY 6,116.00


货期*
4周

规格
    • 200 ug

Product images

Specifications

Product Data
Clone Name MEM-233
Applications FC, IP, WB
Recommend Dilution Flow Cytometry.
Immunoprecipitation.
Western blot (Non-Reducing Conditions).
Reactivity Human
Host Mouse
Clonality Monoclonal
Specificity This antibody recognises the CD80 cell surface antigen, also known as B7-1. 
Functional studies using Mouse anti Human CD80, clone MEM-233 in combination with Mouse anti Human CD86, clone Bu63 suggest that clone MEM-233 is able to block binding of human CD80 with it's cognate ligands CD28 and CTLA-4 (Morbach et al. 2011).
Formulation PBS containing 0.09% Sodium Azide
State: Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name CD80 molecule
Background CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines.
CD80 is expressed by activated B cells, and is important in B cell - T cell interactions, being a ligand of CD28 and CD152 (CTLA-4).
Synonyms CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...