CD55 / DAF Mouse Monoclonal Antibody [Clone ID: MEM-118]

Specifications

Product Data
Clone Name	MEM-118
Applications	FC, IHC, IP
Recommend Dilution	Flow Cytometry: 10 µg/ml. Immunoprecipitation. Immunohistochemistry on Paraffin Sections: 10 μg/ml.
Reactivity	Human, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	HPB-ALL human T cell line
Specificity	The antibody recognizes an epitope in SCR4 domain of CD55 (Decay accelerating factor, DAF), a 60-70 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein. CD55 is widely expressed on hematopoietic and on many non-hematopoietic cells; it is weakly present on NK cells.
Formulation	Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0 State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Precipitation Methods and Size-Exclusion Chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD55 molecule (Cromer blood group)
Database Link	Entrez Gene 1604 Human UniProt ID P08174
Background	CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can still regulate complement when bound to CD97. In tumours, besides protection agains complement, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis.
Synonyms	CR; CROM; DAF; TC
Reference Data

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